Would you like to participate in a research study for the prevention of Chlamydia and Gonorrhea?

We are inviting you to take part in a research study for women 18 years of age or older who had a Chlamydia or Gonorrhea infection within the past 4 months. All study-related visits, tests, and investigational product will be provided at no cost to you. In addition, compensation for time and travel may be provided. Health insurance is not required.

The EVOGUARD study is evaluating the safety and efficacy of an investigational product (EVO100 vaginal gel) to prevent Chlamydia and Gonorrhea infections.

You may qualify for the EVOGUARD study if:

  • You are a female 18 years of age or older
  • You are sexually active
  • You had a Chlamydia or Gonorrhea infection in the past 4 months
  • You are not pregnant or actively trying to become pregnant
Volunteers who take part in the study may receive compensation for time and travel.
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What happens if I sign up? We will match you to a research study location in your area that needs women who had a Chlamydia or Gonorrhea infection in the past 4 months or notify you when a study site becomes available. A member of the study team will contact you and you may have the opportunity to participate if qualified.


If you think you would like to participate in the EVOGUARD study or would like more information, please enter your information below so we can contact you about the study to see if you qualify. Keep in mind that participation is entirely voluntary. If you do decide to take part in a study, you may change your mind about participating at any time.

About the EVOGUARD study

The EVOGUARD study will enroll about 1730 women, who had a Chlamydia or Gonorrhea infection in the past 4 months, at approximately 90 clinical study sites in the US.

Participants will receive all study-related visits, tests, gynecological exams, and investigational product from a dedicated medical team at no cost.

In addition to the screening visit, the study will include 6 visits to the clinical study site in your location over approximately 5 months.

Volunteers who qualify to take part in the study may receive compensation for time and travel.

Who can take part in the EVOGUARD study?

You may be able to take part in the study if:

  • You are a female 18 years of age or older
  • You are sexually active
  • You had a Chlamydia or Gonorrhea infection in the past 4 months
  • You are not pregnant or actively trying to become pregnant

All study-related care is provided by a Health Care Professional.

In this study, researchers are evaluating the safety and efficacy of an investigational product (EVO100 vaginal gel) to prevent Chlamydia and Gonorrhea infections.

Frequently Asked Questions

What is a research study?

A research study (also called a clinical trial) is a medical study that helps to answer important questions about an investigational product – these may include how well an investigational study product works for a certain condition. All medications and products must be tested and evaluated in clinical research studies before they are approved by the FDA and prescribed to patients.

A clinical research study is the process by which new and innovative medications, interventions and treatments are approved and brought to market, so people can live happier and healthier lives. Even over-the-counter medications, such as NSAIDs, you may have used to counteract a headache, have gone through the clinical research study process before it was available at your local pharmacy.

The purpose of this study is to assess the effectiveness of EVO100 vaginal gel in preventing a Chlamydia or Gonorrhea infection, and to evaluate its safety (including your perception of how any side effects impact you) over approximately 16 weeks of treatment.

This study is being conducted at multiple study sites and you will be one of 1730 women (greater than or equal to 18 years old) participating at about 90 study centers in the United States (US). The study has 3 parts: screening, use of EVO100 vaginal gel or placebo for up to 16 weeks, and then a post intervention follow-up 4 weeks after study medication completion or early discontinuation from study.

After a screening period of up to 35 days, women will be placed at random into a group receiving either EVO100 vaginal gel or the placebo gel (The placebo gel looks and feels similar to the investigational gel but does not prevent Chlamydia or Gonorrhea infection). You will have a 50% (1 in 2) chance of receiving EVO100 vaginal gel, and a 50% (1 in 2 – like a flip of a coin) chance of receiving placebo gel. Neither you nor the study doctor can choose or know whether you receive EVO100 vaginal gel or placebo gel.

Your total length of participation in this study is expected to be approximately 25 weeks which includes up to 35 days of screening.

Volunteers who qualify to take part in the study may receive compensation for time and travel. Please discuss this with the study team when they contact you.

There is no cost to participate in the EVOGUARD study. If you qualify, all study-related visits, tests, and investigational product will be provided at no cost to you. If you decide to take part:

  • You will receive study-related care throughout the study from a team of experienced doctors and nurses
  • All study-related visits, tests, and investigational product will be provided at no cost.

The research team will be able to explain more about what the EVOGUARD study will involve so you can make an informed decision on whether you would like to participate in the study or not. Participation in this study is voluntary. Whether or not you decide to participate in this study will not affect your current or future relationships with your doctors. If you decide to participate, you are free to withdraw at any time during the study without affecting those relationships. With your consent, your family doctor and/or specialists can be notified of your progress throughout the duration of the program.

We match you to a study site within a close travel distance from your home. If we are not running the study in your area currently, with your permission, we will keep you in our database and reach out once a study in your area becomes available. If, at any time, you decided you no longer want your information stored, you can opt out and we will delete your details.

About Chlamydia and Gonorrhea

Chlamydia and Gonorrhea are both common sexually transmitted infections (STIs), that are spread from person-to-person, through sexual contact.1

Chlamydia remains the most frequently reported infectious disease in the United States (US).1 This can be passed from person-to-person through vaginal, oral, or anal sex. If you catch Chlamydia, you may not notice the symptoms for a few weeks, and some people may not have any symptoms at all.2

Those who do have symptoms may experience:

  • Burning pain during urination
  • Abnormal vaginal or penile discharge
  • Abnormal rectal discharge
  • Bleeding from the rectum

The symptoms of Chlamydia and Gonorrhea share a number of similarities. Gonorrhea is the second most frequently reported infectious disease in the United States (US).1 Many doctors will treat both infections at once, since it is common that they can occur at the same time.

These infections, especially when untreated, can result in serious consequences including pelvic inflammatory disease (PID), scarring, chronic pelvic pain, ectopic pregnancy and infertility.

Currently, the only options available for prevention of Chlamydia and Gonorrhea infection are consistent and correct use of condoms or abstaining from sexual activity.

The EVOGUARD study is evaluating the safety and efficacy of an investigational product (EVO100 vaginal gel) to prevent Chlamydia and Gonorrhea infections.